Berkemyol® Green Tea

Proprietary preclinical studies

The antioxidant properties of Berkemyol®Green Tea was assessed ex vivo  by quantifying lipid peroxidation through measurement of malondialdehyde (MDA) levels, a by-product of free radical degradation, in viable human skin explants. Results showed a reduction in MDA levels in the presence of Berkemyol® Green tea, after 4 days with fourfold the antioxidant efficacy of vitamin E, considered as an antioxidant reference in cosmetology.

The anti-pollution effect of Berkemyol ® Green Tea  was assessed ex vivo  by quantifying  HIF-1-α factor rate, a molecular marker to evaluate cellular resistance to induced hypoxic stress, in human explants exposed to pollution (Pollubox®). Results showed that Berkemyol ® Green Tea significantly decreases HIF-1-α factor rate, demonstrating its ability to  protect the skin from induced hypoxic stress and to help to re-oxygenate the skin.

The expression of collagen type IV and fibrillin-1, a key component of elastic fibres, was evaluated ex vivo on human skin explants using immunostaining after six days. Application of Berkemyol® Green Tea was found to stimulate collagen type IV and fibrilin-1 expression, demonstrating beneficial effects on skin firmness and elasticity.

Proprietary in vivo study

Berkemyol® Green Tea was evaluated at a 0.5% concentration in a placebo-controlled study, applied twice daily as a cream to one side of the face, with a placebo cream applied to the other side. The trial involved 18 female smokers with dull complexions and facial skin slackening, living in a polluted urban environment. After 28 days, Berkemyol® Green Tea produced a significant increase in skin oxygenation, confirming its capacity to re-oxygenate the skin and help prevent premature aging caused by urban pollution.

Recommended dose

• 0.1% to 0.3%
• Incorporation in oily phase

Claims

• Prevents aging by combating oxidative stress
• Reoxygenates skin tissue, preventing premature skin aging
• Protects the skin against hypoxic stress
• Maintains skin elasticity by stimulating the synthesis of collagen IV and fibrillin-1
• Boosts skin glow & improves skin radiance

Application

• Anti-aging products, skin care and aging prevention products
• Daily protection products
• Anti-pollution products
• Urban skincare
• Make up with skin care properties

After 28 days of using a face cream containing 0.5% of Berkemyol® Green Tea:

• 79% of volunteers felt that their skin was protected from pollution
• 79% of volunteers felt that their complexion was fresh and unified
• More than 7 out of 10 people felt that their skin breathed*

After 7 days of using a face product containing 0.1% of Berkemyol® Green Tea:

• More than 9 out of 10 people felt that their skin is glossier**

* Placebo-controlled human study on 18 female smokers with a dull complexion and sagging facial skin, who applied the product twice daily as a cream containing 0.5% Berkemyol® Green tea to one side of their face, while a placebo cream was applied to the other side.

** Human study conducted by Phytotech (Asia) on 33 participants with dull complexion, dry skin, lack of gloss on the face, who applied a product containing 0.1% Berkemyol® Green tea, twice a day (in the morning and evening), for 28 days.